ABSTRACT
Prostaglandins in the tumor microenvironment block IL-2-induced expansion of killer T cells.
Subject(s)
Interleukin-2 , Tumor Microenvironment , Interleukin-2/immunology , Interleukin-2/metabolism , Humans , Tumor Microenvironment/immunology , Animals , Neoplasms/immunology , Neoplasms/metabolism , Prostaglandins/metabolismABSTRACT
Highlights from the Science family of journals.
ABSTRACT
Microglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner.
Subject(s)
Alzheimer Disease , Humans , Alzheimer Disease/drug therapy , Lipids , Apolipoproteins E/geneticsABSTRACT
Highlights from the Science family of journals.
ABSTRACT
Highlights from the Science family of journals.
ABSTRACT
ATP released by osteoblasts signals through the purinergic receptor P2RX4 to optimize plasma cell survival.
Subject(s)
Osteoblasts , Plasma Cells , Cell SurvivalABSTRACT
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
Subject(s)
DNA Breaks, Double-Stranded , Nucleotidyltransferases , Nucleotidyltransferases/geneticsABSTRACT
The noncanonical caspase caspase-4 processes the pro form of IL-18 in response to LPS.
Subject(s)
Caspases , Lipopolysaccharides , Caspase 1ABSTRACT
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell-driven myelin perturbation.
Subject(s)
Demyelinating Diseases , Humans , Animals , Axons , Myelin Sheath , Microglia , Disease Models, AnimalABSTRACT
Catecholamines associated with stress promote T cell exhaustion through the ß1-adrenergic receptor.
Subject(s)
Catecholamines , T-LymphocytesABSTRACT
Highlights from the Science family of journals.
ABSTRACT
Interferon-ε has antitumor activity and activates antitumor immunity in ovarian cancer in mice.
Subject(s)
Interferons , Ovarian Neoplasms , Animals , Mice , Female , Humans , Ovarian Neoplasms/drug therapyABSTRACT
Loss of phosphatidylinositol transfer protein alpha underlies pancreatic ß cell failure.
Subject(s)
Insulin-Secreting Cells , Insulin-Secreting Cells/metabolismABSTRACT
Adrenergic receptor stimulation improves cancer immunotherapy in a range of immune-competent tumor models.
Subject(s)
Camping , Neoplasms , Humans , Models, Theoretical , Neoplasms/therapy , ImmunotherapyABSTRACT
Remodeling of neural circuits by glioma cells decreases patient survival.
Subject(s)
Brain Neoplasms , Glioma , Humans , Glioma/genetics , Signal Transduction , Neurons , Brain Neoplasms/geneticsABSTRACT
Highlights from the Science family of journals.
ABSTRACT
STING activity in cancer cells prevents the progression of dormant metastasis.
ABSTRACT
LncRNA-derived peptides enhance T lymphocyte responses to tumors in mice.
Subject(s)
Neoplasms , RNA, Long Noncoding , Animals , Mice , Neoplasms/genetics , Neoplasms/therapyABSTRACT
Apical constriction and neural tube closure depend on coordinated ephrin and Wnt signaling.
Subject(s)
Neural Plate , Neural Tube , MorphogenesisABSTRACT
The multilocular phenotype of brown adipose tissue is determined by an ER-lipid droplet anchoring protein.
